The present invention relates to: an antibody capable of binding to myelin oligodendrocyte glycoprotein (MOG) or an antibody fragment thereof； a hybridoma capable of producing the antibody or the antibody fragment； a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment； a transformant cell containing a vector carrying the nucleic acid； a method for producing the antibody or the antibody fragment； a composition containing the antibody or the antibody fragment； and a method for detecting or measuring an antigen occurring in brain, a method for diagnosing or treating a brain disease, a method for improving the accumulation of an antibody in brain, and a method for increasing the amount of an antibody in brain, in each of which the antibody or the antibody fragment is used.本發明係關於一種結合至髓鞘寡樹突細胞糖蛋白質(myelin oligodendrocyte glycoprotein；MOG)之抗體或該抗體片段、產生該抗體或該抗體片段之融合瘤、包含編碼該抗體或該抗體片段之鹼基序列之核酸、含有包含該核酸之載體之轉形細胞、該抗體或該抗體片段之製造方法、包含該抗體或該抗體片段之組合物、以及使用該抗體或該抗體片段之檢測或測定存在於腦中之抗原之方法、診斷或治療腦疾病之方法、使抗體之腦滯留性提高之方法、及使腦內之抗體量增加之方法。
