Stoit, Axel,Iwema Bakker, Wouter I.,Coolen, Hein K.A.C.,van Dongen, Maria J.P.,Leflemme, Nicolas J.-L.D.,Hobson, Adrian D.
申请号：
AU2015255181
公开号：
AU2015255181A1
申请日:
2015.11.10
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015255181A120151126.pdf#####Abstract The present invention relates spiro-cyclic amine derivatives of the formula (I) R2 R1 -Y-(Cn-aIkyIene)-X 0 z- A N-R3 W-T R5 () wherein R1 is selected from cyano, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkyl each optionally substituted with CN or one or more fluoro atoms, (3-6C)cycloalkyl, (4-6C)cycloalkenyl or a (8-10C)bicycic group, each optionally substituted with halogen or (1-4C)alkyl, phenyl, biphenyl, naphthyl, each optionally substituted with one or more substituents independently selected from halogen, cyano, (1-6C)alkyl optionally substituted with one or more fluoro atoms, (1-6C)alkoxy optionally substituted with one or more fluoro atoms, amino, di(1-4C)alkylamino and (3-6C)cycloalkyl optionally substituted with phenyl which may be substituted with (1-4C)alkyl or halogen, phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocycic heterocycle, each optionally substituted with (1-4C)alkyl optionally substituted with one or more fluoro atoms, monocyclic heterocycle optionally independently substituted with halogen, (1-6C)alkyl optionally substituted with one or more fluoro atoms, (3-6C)cycloalkyl, or phenyl optionally substituted with (1-4C)alkyl or halogen, andbicyclic heterocycle optionally substituted with halogen or (1-4C)alkyl optionally substituted with one or more fluoro atoms -Y-(C 1o-alkylene)-X- is a linking group wherein Y is attached to R1 and selected from a bond, -0-, -CO-, -S-, -SO-, -SO 2-NH-, -CH=CH-, -C(CF3)=CH-, -C-C-, -CH2-0-, -O-CO-, -CO-0-CO-NH-, -NH-CO-, and trans-cyclopropylene n is an integer from 0 to 10 and X is attached to the phenylene/pyridyl moiety and selected from a bond, -O-, -S-, -SO-, -SO 2-, -NH-, -CO-, -CH=CH-, and trans-cyclopropylene R2 is H or independently selected from one or more substituents selected from halogen, (1-4C)alkoxy and (1-4C)alkyl optionally substituted with one or more fluor atoms and R3 is (1-4C)alkylene-R4 wherein the alkylene group may be s
