FIELD: chemistry.SUBSTANCE: invention relates to a cyclic amine derivative of formula (I),where R1 is an alkoxy group having 1–3 carbon atoms, any 1–3 hydrogen atoms of which are optionally replaced with a halogen atom(s)； R2 is a halogen atom； R3 represents a hydrogen atom, a halogen atom or a hydroxy group； R4 is a hydrogen atom or a halogen atom； X is -C(=O)-(CH2)n-R5 or -S(=O)2-R6； n is integer from 0 to 5； R5 is a hydrogen atom, -OR7, -SR7, -S(=O)2-R7, -C(=O)-OR7, -N(R7)R8, an alkyl group having 1–3 carbon atoms, any 1–3 hydrogen atoms of which are optionally replaced with a halogen atom(s), or 5-membered ring heteroaryl group containing 1 to 4 heteroatoms independently selected from a group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, any hydrogen atom(s) of which is optionally replaced by an alkyl group(s) having 1–3 carbon atoms； R6 is an alkyl group having 1–5 carbon atoms； R7 represents a hydrogen atom or an alkyl group having 1–3 carbon atoms, any 1–3 hydrogen atoms of which are optionally replaced with a halogen atom(s)； and R8 represents a hydrogen atom, an alkyl group having 1–3 carbon atoms, an acyl group having 2–4 carbon atoms, or an alkylsulphonyl group having 1–3 carbon atoms, or a pharmaceutically acceptable salt thereof.EFFECT: disclosed is a cyclic amine derivative which has retinoid orthophanic receptor antagonist activity γ and has a therapeutic effect or preventive effect on autoimmune diseases.11 cl, 12 dwg, 3 tbl, 74 exИзобретение относится к производному циклического амина формулы (I)где R1 представляет собой алкоксигруппу, имеющую 1-3 атома углерода, любые 1-3 атома водорода которой необязательно заменены атомом(ами) галогена； R2 представляет собой атом галогена； R3 представляет собой атом водорода, атом галогена или гидроксигруппу； R4 представляет собой атом водорода или атом галогена； X представляет собой -C(=O)-(CH2)n-R5 или -S(=O)2-R6； n равен целому числу от 0 до 5； R5 представляет собой атом водорода, -OR7, -SR7
