Synthesis of decitabine

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专利权人:

Ltd.;ScinoPharm Taiwan

发明人:

Henschke, Julian Paul,Zhang, Xiaoheng,Yu, Jianbo,Hu, Kun,Mei, Lijun

申请号：

AU2010291893

公开号：

AU2010291893B2

申请日:

2010.02.04

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

A method for producing a β-enriched protected decitabine comprising: a) coupling a protected 2-deoxy-ribofuranose with a protected 5-azacytosine in the presence of a catalyst to form a reaction mixture comprising the protected decitabine of formula (I)； and b) quenching the reaction mixture of step a) with a base. The β-enriched protected decitabine so made may be deprotected to produce a decitabine product in a high yield and purity.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/