Berberich, David Wayne,Jiang, Tao,Wang, Peter X.,Cantrell, Gary L.
申请号：
AU2008231127
公开号：
AU2008231127B2
申请日:
2008.03.14
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
An improved method for the preparation of oxymorphone from oripavine is provided. Oripavine is oxidized to form 14-hydroxymorphinone after which the oxidation reaction is quenched to prevent the formation of 1-1-dimer side products. The 14-hydroxymorphinone is then reduced, typically by catalytic hydrogenation to form oxymorphone. The inventive method disclosed is further applicable to the production of morphinan derivatives.
