PAISLEY, STEVEN, D.,LEPREE, JASON, M.,HAWI, AMALE,ECKHOFF, MICHAEL
申请号：
SG2012066437
公开号：
SG184787A1
申请日:
2011.03.09
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
The present invention is directed to a method of synthesizing a compound of Formula I: the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base； (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol； and (c) oxidizing the alpha-tocopherol of I (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/aipha-tocopherol is 1.6 to 4.
