WANG, PETER X.,JIANG, TAO,CANTRELL, GARY L.,BERBERICH, DAVID WAYNE
申请号：
PL08732176
公开号：
PL2125824T3
申请日:
2008.03.14
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
An improved method for the preparation of oxymorphone from oripavine is provided. Oripavine is oxidized to form 14-hydroxymorphinone after which the oxidation reaction is quenched to prevent the formation of 1-1&prime；-dimer side products. The 14-hydroxymorphinone is then reduced, typically by catalytic hydrogenation to form oxymorphone. The inventive method disclosed is further applicable to the production of morphinan derivatives.
