BAXTER, ANTHONY DAVID,BOYD, EDWARD ANDREW,GUICHERIT, OIVIN M.,PORTER, JEFFREY,PRICE, STEPHEN,RUBIN, LEE E.,FRANK-KAMENETSKY, MARIA
申请号：
CA2404413
公开号：
CA2404413C
申请日:
2001.03.30
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention makes available methods and reagents for modulatingproliferation or differentiation in a cell or tissue comprising contacting thecell with a hedgehog agonist, such as the compounds depicted in Figures 32 and33. In certain embodiments, the methods and reagents may be employed tocorrect or inhibit an aberrant or unwanted growth state, e.g., by antagonizinga normal ptc pathway or agonizing smoothened orhedgehog activity.
