A composition is disclosed that includes formulation A, wherein formulation A comprises pyrroloquinoline quinone (PQQ), coenzyme Q (CoQ10), niacinamide and riboflavin in a combined amount sufficient to increase mitochondrial mass in a cell. In some embodiments, the composition also includes formulation B, wherein formulation B comprises a magnesium chelate, iron, a copper salt, a manganese salt, a molybdenum salt, a zinc salt, and organic selenium. The disclosed compositions are of use for increasing mitochondrial biogenesis in a cell of a subject, increasing the activity level or exercise capacity of a subject, and/or increasing alertness and/or cognition.
