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N-ACYL CYCLIC AMINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
专利权人:
发明人:
申请号:
EP11753530.2
公开号:
EP2545046A1
申请日:
2011.03.11
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention provides compounds which show high effectiveness against positive symptoms, negative symptoms and cognitive dysfunction in schizophrenia and reduce conventional side-effect risks as well as have remarkable effects for central neurological diseases associated with cognitive dysfunction other than schizophrenia. N-Acyl cyclic amine derivatives of formula (1): wherein Ar1 and Ar2 are aryl or heteroaryl V is nitrogen, or CR3 W1 is a single bond, -C(O)-, etc. W2 is C1-alkylene W3 is a single bond, methylene, -NH-, -CR4=CR5-, etc. Ring Q is a group of formula (a) in which n is 0 or 1 m is 0 to 2 k is 1 to 3 Z is a single bond, methylene, oxygen, etc. R1a, R1b and R1c are each, same or different, hydrogen, hydroxyl, halogen, cyano, C1-6 alkyl, etc. or pharmaceutically acceptable salts thereof are provided.
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