VECTEURS DE SALMONELLA TYPHI VIVANTS MODIFIES POUR EXPRIMER DES ANTIGENES DE PROTEINES DE MEMBRANE EXTERNE HETEROLOGUES ET LEURS PROCEDES D'UTILISATION
UNIVERSITY OF MARYLAND, BALTIMORE;NATIONAL RESEARCH COUNCIL OF CANADA
发明人:
GALEN, JAMES E.,PHAM, THANH,BRIDGE, DACIE R.,WANG, JIN YUAN,CHEN, WANGXUE C.,CHEN, WANGXUE
申请号：
CA3063419
公开号：
CA3063419A1
申请日:
2018.05.15
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.
