COMPOSITIONS AND METHODS OF STIMULATING AND EXPANDING T CELLS

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专利权人:

发明人:

Yangbing Zhao,Xiaojun Liu,Carl H. June

申请号：

US15521741

公开号：

US20170258836A1

申请日:

2015.10.30

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention includes a method for expanding a population of electroporated T cells. The method includes electroporating a population of cells comprising T cells with mRNA encoding a chimeric membrane protein comprising an antigen binding domain to a molecule and an intracellular domain of a co-stimulatory molecule, wherein the cultured T cells expand at least 10 fold. The invention further includes an expanded population of T cells, compositions comprising the cells and methods of treatment.

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中国工程科技知识中心

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http://www.ckcest.cn/home/