Compositions and methods of stimulating and expanding T cells

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专利权人:

The Trustees of the University of Pennsylvania

发明人:

Zhao, Yangbing,Liu, Xiaojun,June, Carl H.

申请号：

AU2015339106

公开号：

AU2015339106A1

申请日:

2015.10.30

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The present invention includes a method for expanding a population of electroporated T cells. The method includes electroporating a population of cells comprising T cells with mRNA encoding a chimeric membrane protein comprising an antigen binding domain to a molecule and an intracellular domain of a co-stimulatory molecule, wherein the cultured T cells expand at least 10 fold. The invention further includes an expanded population of T cells, compositions comprising the cells and methods of treatment.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/