Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is a thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.式I之吡唑-4-基-雜環甲醯胺化合物，包括其立體異構體、幾何異構體、互變異構體及醫藥學上可接受之鹽，其中X為噻唑基、吡嗪基、吡啶基或嘧啶基，可用於抑制Pim激酶，且可用於治療Pim激酶介導之病症，諸如癌症。本發明揭示使用式I化合物在活體外、原位及活體內診斷、預防或治療哺乳動物細胞之該等病症或相關病理病狀的方法
