SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;서울대학교 산학협력단
发明人:
KIM, Byeong Moon,김병문,RYU, Eun Ju,류은주,PARK, Ji Su,박지수,LI, Linzi,이림자
申请号：
KRKR2019/005844
公开号：
WO2019/221513A1
申请日:
2019.05.15
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a novel brominated furanone derivative, a method for preparing same and a pharmaceutical composition containing same as an active ingredient. A novel brominated furanone derivative or pharmaceutically acceptable salts thereof according to the present invention exhibit quorum sensing inhibitory activity of bacteria and allow effective inhibition of the formation of a biofilm of bacteria and inhibition of bacterial growth, and thus are used as a pharmaceutical composition, a functional health food composition, an antibiotic composition, a toothpaste composition or a mouthwash composition containing same as an active ingredient, and thus can exhibit useful effects on oral diseases or inflammatory diseases, e.g. periodontal diseases and the like such as gingivitis and periodontitis.La présente invention concerne un nouveau dérivé de furanone bromé, un procédé de préparation de celui-ci et une composition pharmaceutique le contenant en tant que principe actif. Le nouveau dérivé de furanone bromé ou des sels pharmaceutiquement acceptables de celui-ci selon la présente invention présentent une activité inhibitrice de détection de quorum de bactéries et permettent une inhibition efficace de la formation d'un biofilm de bactéries et l'inhibition de la croissance bactérienne, et sont ainsi utilisés en tant que composition pharmaceutique, composition d'aliment santé fonctionnel, composition antibiotique, composition de dentifrice ou composition de bain de bouche contenant celui-ci en tant que principe actif, et peut ainsi présenter des effets utiles sur des maladies buccales ou des maladies inflammatoires, par exemple des maladies parodontales et similaires telles que la gingivite et la parodontite.본 발명은 신규한 브롬화 퓨라논 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물에 관한 것으로, 본 발명에 따른 신규한 브롬화 퓨라논 유도체 또는 이의 약학적으로 허용 가능한 염은 세균의 쿼럼센싱 억제 활성을 나타내며, 또한, 세균의 생물막(biofilm) 형성을 효과적으로 억제할 수 있고, 세균 생장을 억제할 수 있는 바, 이를 유효성분으로 함유하는 약학적 조성물, 건강기능식품 조성물, 항생제 조성물, 치약 조성물, 또는
