BARRETT, Robert,SVENDSEN, Clive,TARGAN, Stephan R.,WORKMAN, Michael,SAREEN, Dhruv,RAJAMANI, Uthra
申请号：
WO2018US33498
公开号：
WO2018213773(A1)
申请日:
2018.05.18
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
Induced pluripotent stem cell (iPSC)-based organoid technology has tremendous potential to elucidate the intestinal and colonic epithelium's role in health and disease. Described herein are methods and compositions for generation of intestinal and colonic cells from iPSCs. Derivation of iPSCs from subjected afflicted with early onset and very early onset Inflammatory Bowel Disease (IBD), serves as an excellent model for understanding disease pathogenesis.
