pH-SENSITIVE CARRIER AND METHOD FOR PRODUCTION THEREOF, pH-SENSITIVE MEDICINE AND pH-SENSITIVE PHARMACEUTICAL COMPOSITION EACH CONTAINING SAID CARRIER, AND CULTURE METHOD USING SAID pH-SENSITIVE MEDICINE OR SAID pH-SENSITIVE PHARMACEUTICAL COMPOSITION
Provide: a pH-sensitive carrier is used as an a kind of bracket of physiological activator and can respond a weakly acidic environment to show the effect for promoting a film-to make function A method of for generating pH-sensitive carrier The medicine of one pH sensitivities and a pH-sensitive Pharmaceutical composition each include bracket Use the medicine of pH sensitivities or a cultivation of pH-sensitive Pharmaceutical composition. One pH-sensitive carrier, it can show the effect for promoting a film-to make function, say the pH-sensitive carrier for including: at least one pH-sensitive compound, it is selected from group, is made of deoxycholic acid, cholic acid, cholanic acid, chenocholic acid, hyodeoxycholic acid, a higher bile acid, sweet amine deoxycholic acid, glycyrrhizic acid, enoxolone and its salt There is the substance of hydrophilic and hydrophobic part to be selected from the group being made of the monophosphatide phatidylcholine with 10 to 12 carbon atoms, a polyoxyethylene sorbitan fatty acid ester, a sorbitan fatty acid ester with 12 to 18 carbon atoms simultaneously at least one, with 16 to 18 carbon atoms, Monoolein, glycerol dilaurate, distearin, diolein, Emulsifier EL-60 and alpha-tocopherol.
