蛍光組織マーカー及びその製造方法
- 专利权人:
- 国立大学法人;千葉大学
- 发明人:
- 豊田 太郎,畑山 博哉,林 秀樹,藤浪 眞紀
- 申请号：
- JP2009119338
- 公开号：
- JP5765695B2
- 申请日:
- 2009.05.15
- 申请国别(地区):
- JP
- 年份:
- 2015
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide a fluorescent tissue marker which can be located even from the outside of an organ and which can topically stay there for a long time and to provide its production method.
SOLUTION: There is provided a fluorescent tissue marker having vesicle clusters prepared by allowing vesicles resulting from the conjugation of a phospholipid and a near-infrared fluorophore to be occluded in a hydrophilic solvent, forming a plurality of capsules with the aid of an emulsifier and coagulating them. There is also provided a method for producing a fluorescent marker comprising adding a near-infrared fluorophore and a phospholipid to a first hydrophilic solvent under agitation, adding the first hydrophilic solvent and an emulsifier to a hydrophobic solvent to form a suspension, and centrifuging the formed suspension by using a second hydrophilic solvent.
COPYRIGHT: (C)2011,JPO&INPIT
- 来源网站：
- 中国工程科技知识中心
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