David F. OBrien,Kathy A. McGovern,Bruce Bondurant,Robert Sutherland
申请号：
US13609058
公开号：
US20130053618A1
申请日:
2012.09.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
