DÉRIVÉS DE PYRAZOLIDINE-3-ONE

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专利权人:

F.HOFFMANN-LA ROCHE AG

发明人:

申请号：

EP12716007.5

公开号：

EP2702050B1

申请日:

2012.04.23

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates to ethynyl derivatives of formula I wherein G, X, R1, R2, R3, R3', R4, and R4' are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5).

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