Georg Jaeschke;Lothar Lindemann;Heinz Stadler;Eric Vieira;Synese Jolidon
发明人:
Georg Jaeschke,Synese Jolidon,Lothar Lindemann,Heinz Stadler,Eric Vieira
申请号：
US13452973
公开号：
US08957213B2
申请日:
2012.04.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula IX, G, R1, R2, R3, R3′, R4, R4′, R5, R6, R6′, m, and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5). They can be used for the treatment of schizophrenia or cognitive disorders.
