Georg Jaeschke;Daniel Rueher;Eric Vieira;Antonio Ricci;Lothar Lindemann;Heinz Stadler;Synese Jolidon
发明人:
Georg Jaeschke,Synese Jolidon,Lothar Lindemann,Antonio Ricci,Daniel Rueher,Heinz Stadler,Eric Vieira
申请号：
US13454167
公开号：
US08648088B2
申请日:
2012.04.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula Iwherein G, X, R1, R2, R3, R3′, R4, and R4′ are as defined hereinor to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. Compounds of formula I are positive allosteric modulators (PAM) of the metabotropic glutamate receptor subtype 5 (mGluR5).
