PROBLEM TO BE SOLVED: To provide a method for treatment of disorders characterized by the overexpression of ErbB2.SOLUTION: A method for treatment comprises: administering an effective amount of an anti-ErbB2 antibody to the human patient； administering to the patient an initial dose of at least approximately 5 mg/kg of the anti-ErbB2 antibody； and administering to the patient a plurality of subsequent doses of the antibody in an amount that is approximately the same or less than the initial dose. The initial dose is selected from the group consisting essentially of approximately 6 mg/kg, 8 mg/kg, or 12 mg/kg, wherein the plurality of subsequent doses are at least approximately 2 mg/kg, and wherein the subsequent doses are separated in time from each other by at least one week.【課題】ＥｒｂＢ２の過剰発現によって特徴付けられる疾患の治療方法の提供。【解決手段】ヒト患者に抗ＥｒｂＢ２抗体の有効量を投与することを含み：少なくとも約５ｍｇ／ｋｇの抗ＥｒｂＢ２抗体の初期投与量を患者に投与し；さらに抗体の複数回のその後の投与量を初期投与量とおよそ同量又はより少量である量で患者に投与する。初期投与量が、本質的に約６ｍｇ／ｋｇ、８ｍｇ／ｋｇ、又は１２ｍｇ／ｋｇからなる群から選択され、複数回のその後の投与量が少なくとも約２ｍｇ／ｋｇであり、その後の投与量が互いに少なくとも１週間の間隔をおかれる。【選択図】図１
