PROBLEM TO BE SOLVED: To provide methods for treating diseases characterized by the overexpression of ErbB2, such as cancer.SOLUTION: Disclosed is a method comprising administering an initial dose of at least about 5 mg/kg of anti-ErbB2 antibody to a patient and subsequently further administering to the patient multiple times an amount of antibody that is about the same amount or less than the initial dose. Preferably, the subsequent administration is performed after the interval of at least one week from the initial administration. Preferably, the initial administration is intravenously performed and subsequent administration is subcutaneously performed.SELECTED DRAWING: Figure 1【課題】癌等のＥｒｂＢ２の過剰発現によって特徴付けられる疾患を治療するための方法の提供。【解決手段】少なくとも約５ｍｇ／ｋｇの抗ＥｒｂＢ２抗体の初期投与量を患者に投与し、その後、さらに初期投与量とおよそ同量又はより少量である量の抗体を複数回患者に投与することを含む方法。その後の投与が、初期投与後少なくとも１週間の間隔をおかれるのが好ましい。また、初期投与が静脈内注射により投与され、その後の投与が皮下注射により投与されることが好ましい。【選択図】図１
