The University Court of the University of Edinburgh;University of Maryland;Washington State University
发明人:
OATLEY, John Michael,WHITELAW, Christopher Bruce Alexander,LILLICO, Simon Geoffrey,TELUGU, Bhanu Prakash
申请号：
AU2018204794
公开号：
AU2018204794A1
申请日:
2018.06.29
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018204794A120180719.pdf#####C: Interwon NRPortbl DCC AMT 17249191-ldocx-29 06 2018 ABSTRACT The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.
