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NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS
专利权人:
发明人:
申请号:
EP15821460.1
公开号:
EP3169778A2
申请日:
2015.07.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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