Washington State University;University of Maryland;The University Court of The University of Edinburgh
发明人:
Jon Michael Oatley,Christopher Bruce Alexander Whitelaw,Simon Geoffrey Lillico,Bhanu Prakash Telugu
申请号：
US16825858
公开号：
US20200253174A1
申请日:
2020.03.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.
