The present invention discloses a hydrophobic and oleophobic cosmetic pigment powder, including pigment powder and a skin-fitting treatment agent. The skin-fitting treatment agent can perform surface compounding treatment on the pigment powder and includes fluorine-containing silane and hydrogenated lecithin. The hydrophobic and oleophobic cosmetic pigment powder has excellent hydrophobic and oleophobic properties, has excellent pickable property and skin-fitting property, and makes skin elastic, soft and smooth. The perfluorinated silane treatment agent in the present invention has a carbon number less than or equal to 8, is safe, skin-friendly and nontoxic, and can achieve effects of nourishing skin and easily removing makeup due to addition of pure plant ingredients with excellent skin affinity.