АЛТМАН Майкл Д.,ЧАЙЛДЕРС Калин Конрад,ДИ ФРАНЧЕСКО Мария Эмилия,ЭЛЛИС Джон Майкл,ФИШЕР Кристиан,ГРИММ Джонатан,ХАЙДЛ Эндрю М.,КАТТАР Соломон Д.,НОРТРУП Алан Б.,ОТТЕ Райан Д.,ПЕТРОККИ Алессия,СКЕЛЛ Ада
申请号：
RU2013154412
公开号：
RU2013154412A
申请日:
2012.05.04
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The compound of formula I: or a pharmaceutically acceptable salt thereof, wherein A is a carbocycle, or the A- (R) (R) group is 1,4-dioxaspiro [4.5] decyl； n is 0, 1, 2 or 3； R is C 1-6 alkyl, C 1-4 fluoroalkyl , Cycloalkyl or Salkoxy； R represents H or a halogen atom； R represents H, a halogen atom, C1-6alkyl, Haloalkyl, Cycloalkyl or Hydroxyalkyl； R represents H or a halogen atom； R represents H, OH, Salkoxy, a halogen atom or NH, R 1 represents Cycloalkyl or hydroxyalkyl； or R and R taken together form oxo； R is selected from OH or C1-6alkyl； R is selected from (CRR) COR, CONRR, tetrazolyl, OH, CHOH, oxo, CN, NHCOR and NHSOR； provided that R and —C (R) (R) are not attached to the same ring carbon atom； R and R are each independently selected from H and methyl； R is H or C1-6alkyl； R and R are each independently selected from H or C1-6alkyl； and R represents C1-6alkyl or benzyl. 2. A compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein ring A is carbocycle. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is C 1-6 alkyl or C 1-4 fluoroalkyl. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R5 is OH.5. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein A is a carbocycle and R is selected from (CRR) COR and CONRR. 6. The compound according to claim 1 of formula Ia: or a pharmaceutically acceptable salt thereof, wherein A is a carbocycle； n is 0, 1 or 2； R is C1-6alkyl or Haloalkyl； R3 is C1-6alkyl, Haloalkyl or Cycloalkyl； R2 is H, C1-6alkyl or Haloalkyl； R3 is C1-6alkyl； CONRR； R represents H or C1-6alkyl； R and R are each independently selected from H or C1-6alkyl. 7. The compound according to claim 1 of formula Ib: or its pharmacy1. Соединение формулы I:или его фармацевтически приемлемая соль,гдеА представляет карбоцикл, илигруппа A-(R)(R) представляет 1,4-диоксаспиро[4.5]децил；n равно 0, 1, 2 или 3；Rпредставляет Салк
