ANTARCTIC MARINE DERIVED ASPERGILLUS SP. SF-5929 PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR

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专利权人:

KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY;한국해양과학기술원

发明人:

YIM JOUNG HAN,임정한,OH HYUN CHEOL,오현철,SOHN JAE HAK,손재학,KIM DONG CHEOL,김동철,TRAN MINH HA,트란밍하

申请号：

KR1020180084114

公开号：

KR1020543920000B1

申请日:

2018.07.19

申请国别(地区):

KR

年份:

2019

代理人:

摘要：

The present invention relates to a marine derived mold Aspergillus sp. derived novel compound. More specifically, the present invention relates to an Aspergillus sp. derived novel diphenol derivative, (±；)-tylopilusin D, and a protein tyrosine phosphatase 1B inhibiting composition containing the (±；)-tylopilusin D or a salt thereof as an active ingredient. The (±；)-tylopilusin D according to the present invention effectively suppresses activity of PTP1B, thereby being useful for treatment of diseases related to the PTP1B such as cancer, diabetes, and obesity.COPYRIGHT KIPO 2020본 발명은 해양 유래 곰팡이 Aspergillussp. 유래 신규 화합물에 관한 것으로, 더욱 자세하게는 Aspergillussp. 유래 신규 다이페놀 유도체 (±)-tylopilusin D 및 상기 (±)-tylopilusin D 또는 그의 염을 유효성분으로 함유하는 단백질티로신포스파타아제 1B의 저해용 조성물에 관한 것으로, 본 발명에 따른(±)-tylopilusin D는 PTP1B 활성을 효과적으로 억제하여, 암, 당뇨, 비만 등 PTP1B 관련된 질환의 치료에 사용될 수 있다.

来源网站：

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