Cold pack apparatus for abstracting heat comprises a container charged with a first liquid and with small auxiliary containers free to circulate in the first liquid. Each of the small auxiliary containers is charged with a second liquid. The first and second liquids each have a selected temperature of transformation that facilitates use of the apparatus to heat or cool a substance contacted by the apparatus. The cold pack apparatus reduces pain at a joint or at a diseased area in the epithelium by producing spaced apart points of cold at the joint or diseased area for an extended period of time of one hours or more.