Hsien-Sheng Yin,Wen-Ting Chen,Hsin-Yu Yang,Chih-Yu Lin
申请号：
US16424693
公开号：
US20190276512A1
申请日:
2019.05.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides a recombinant chicken interleukin-1β protein for producing antibody early and retaining for a longer period of time, which has a sequence of SEQ ID NO:2 or SEQ ID NO:3. The recombinant chicken interleukin-1β protein is created by using point mutation in a genetic engineering method； it can significantly improve the original vaccine efficacy to enhance antibody responses, produce antibody one week earlier and extend the protective effect until chickens sold off. Therefore, the recombinant chicken interleukin-1β protein of the present invention can produce significant higher antibody responses than the with-type chicken interleukin-1β protein, it helps to develop avian interleukin-1β vaccine adjuvant and uses in medical application and livestock production.
