Atoxic recombinant holotoxins of Clostridium difficile as immunogens

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专利权人:

发明人:

Saul Tzipori,Xingmin Sun

申请号：

US14958998

公开号：

US20160166672A1

申请日:

2015.12.04

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Compositions, methods and kits are provided for preparing an atoxic C. difficile protein that elicits an immune response in the subject specific for TcdA and TcdB. Atoxic Clostridium difficile toxin proteins were expressed in an endotoxin-free Bacillus system to develop a vaccine to reduce or treat incidence and severity of C. difficile infection (CDI).

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