The United States of America, as represented by The Secretary, Department of Health and Human Services
发明人:
LENARDO, Michael J.,LI, Jian,ZHENG, Lixin,LEE, Jae W.,LU, Wei
申请号：
EP20160711090
公开号：
EP3268382(A1)
申请日:
2016.03.09
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
Disclosed is a protein comprising no more than three human autoantigenic proteins, wherein a first human autoantigenic protein comprises a truncated myelin oligodendrocyte glycoprotein (MOG) amino acid sequence, a second human autoantigenic protein comprises a myelin basic protein (MBP) amino acid sequence, and a third human autoantigenic protein comprises a truncated proteolipid protein (PLP) amino acid sequence. Also disclosed are related nucleic acids, pharmaceutical compositions, methods of treating a demyelinating disease, and methods of producing the proteins.
