The present invention relates to a thick steel plate having excellent low-temperature toughness and hydrogen-induced cracking resistance, and a method for manufacturing the same. The thick steel plate comprises: one or two kinds of C of 0.02-0.08 weight%, Si of 0.1-0.5 weight%, Mn of 0.8-2.0 weight%, P of 0.03 weight% or less, S of 0.003 weight% or less, Al of 0.06 weight% or less, N of 0.01 weight% or less, Nb of 0.005-0.1 weight%, Ti of 0.005-0.05 weight%, Ca of 0.0005-0.005 weight%, Cu of 0.005-0.3%, and Ni of 0.005-0.5%; and one or more kinds of Cr of 0.05-0.5 weight%, Mo of 0.02-0.4 weight%, and V of 0.005-0.1 weight%; and the balance being Fe and other unavoidable impurities, wherein a carbon equivalent (Ceq) value satisfies 0.45 or less as defined by relational expression 1 below: [relational expression 1] a carbon equivalent (Ceq) = C + Mn/6 + (Cr + Mo + V)/5 + (Cu + Ni)/15 (wherein C, Mn, Cr, Mo, V, Cu, and Ni represent the content of each element by weight%), wherein the weight ratio of Ca/S satisfi
