Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.本發明係提供結合至含有T細胞免疫球蛋白及黏蛋白結構域-3 (TIM3)蛋白之抗體或其抗原結合部分。亦提供該等抗體或其抗原結合部分在治療應用中之用途，例如治療癌症。進一步提供產生該等抗體或其抗原結合部分之細胞、編碼該等抗體或其抗原結合部分之重鏈及/或輕鏈區之多核苷酸、及包含編碼該等抗體或其抗原結合部分之該等重鏈及/或輕鏈區之該等多核苷酸的載體。
