KARAKATSANI, MARIANTHI N.,KUMAR, ANITA,KUMBHANI, DEVJIBHAI D.,THANGAMATHESVARAN, PALLAPALAYAM M.
申请号：
CA2904416
公开号：
CA2904416A1
申请日:
2014.03.07
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Described are stability-enhancing formulations of drugs that are sensitive to moisture. The formulations comprise co-granulates containing a moisture-sensitive drug and an excipient selected from fructose, xylitol, maltitol, and mixtures thereof. Also described are methods of producing a pharmaceutical tablet. The method comprises forming a blend of a moisture- sensitive drug and a first excipient selected from fructose, xylitol, maltitol, and mixtures thereof spraying the blend with water to produce granules drying and milling the granules mixing a second excipient with the granules and compressing into tablets.
