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STABILIZATION OF MOISTURE-SENSITIVE DRUGS
专利权人:
发明人:
申请号:
EP14759989.8
公开号:
EP2964261A1
申请日:
2014.03.07
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
Described are stability-enhancing formulations of drugs that are sensitive to moisture. The formulations comprise co-granulates containing a moisture-sensitive drug and an excipient selected from fructose, xylitol, maltitol, and mixtures thereof. Also described are methods of producing a pharmaceutical tablet. The method comprises forming a blend of a moisture-sensitive drug and a first excipient selected from fructose, xylitol, maltitol, and mixtures thereof spraying the blend with water to produce granules drying and milling the granules mixing a second excipient with the granules and compressing into tablets.
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