Marianthi Karakatsani,Anita Kumar,Devjibhai D. Kumbhani,Pallapalayam M. Thangamathesvaran
申请号：
US15477479
公开号：
US20170202801A1
申请日:
2017.04.03
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Described are stability-enhancing formulations of drugs that are sensitive to moisture. The formulations comprise co-granulates containing a moisture-sensitive drug and an excipient selected from fructose, xylitol, maltitol, and mixtures thereof. Also described are methods of producing a pharmaceutical tablet. The method comprises forming a blend of a moisture-sensitive drug and a first excipient selected from fructose, xylitol, maltitol, and mixtures thereof spraying the blend with water to produce granules drying and milling the granules mixing a second excipient with the granules and compressing into tablets.
