ПРАТЕР, Рэндалл, С. (US),УЭЛЛС, Кевин, Д. (US),УИТВОРТ, Кристин, М. (US)
申请号：
RU2018107842
公开号：
RU2018107842A
申请日:
2016.07.22
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The animals and offspring have chromosomal modifications of a CD163 gene. The invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.
