Randall S. Prather,Kevin D. Wells,Kristin M. Whitworth
申请号：
US15216865
公开号：
US20170035035A1
申请日:
2016.07.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The animals and offspring have chromosomal modifications of a CD163 gene. The invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.
