Randall S. Prather,Kevin D. Wells,Kristin M. Whitworth
申请号：
US16111631
公开号：
US10405526B2
申请日:
2018.08.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.
