Randall S. Prather;Kevin D. Wells;Kristin M. Whitworth
发明人:
Randall S. Prather,Kevin D. Wells,Kristin M. Whitworth
申请号：
US14117943
公开号：
US09820475B2
申请日:
2012.05.16
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The disclosure relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD 163 gene inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSV). Methods for producing such transgenic swine are also provided.
