LE MOAN, Natacha,KROTOLICA, Ana,LEUNG, Philberta,CARY, Stephen
申请号:
SG11201806920S
公开号:
SG11201806920SA
申请日:
2017.02.16
申请国别(地区):
SG
年份:
2018
代理人:
摘要:
The invention provides H-NOX proteins for the delivery of oxygen to hypoxic tissue following stroke. H-NOX proteins extravasate into hypoxic penumbra associated with stroke and preferentially accumulate for sustained delivery of oxygen to the hypoxic tissue to ameliorate adverse affects of stroke related hypoxia. In some embodiments, the H-NOX comprises PEGylated H-NOX and non-PEGylated H-NOX.