Svetlana O. DORONINA,Peter D. SENTER,Brian E. TOKI,Toni Beth KLINE
申请号：
US16507839
公开号：
US20190338045A1
申请日:
2019.07.10
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
