Svetlana O. Doronina,Peter D. Senter,Brian E. Toki,Toni Beth Kline
申请号：
US14194106
公开号：
US20140220047A1
申请日:
2014.02.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
