Svetlana O. Doronina,Peter D. Senter,Brian E. Toki,Toni Beth Kline
申请号：
US15811190
公开号：
US10414826B2
申请日:
2017.11.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
