Michael T. KOWARIK,Michael L. WETTER,Stefan J. KEMMLER,Micha A. HÄUPTLE,Veronica GAMBILLARA,Manuela MALLY
申请号：
US16599900
公开号：
US20200129605A1
申请日:
2019.10.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein is an E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.
