Michael T. Kowarik,Michael L. Wetter,Stefan J. Kemmler,Micha A. Häuptle,Veronica Gambillara,Manuela Mally
申请号：
US15643788
公开号：
US10441647B2
申请日:
2017.07.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.
