Michael T. Kowarik,Michael L. Wetter,Stefan J. Kemmler,Micha A. Häuptle
申请号：
US14628844
公开号：
US20150238588A1
申请日:
2015.02.23
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells comprising enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates comprise O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, comprising O25B and/or bioconjugates comprising O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further comprise one or more additional bioconjugates.
